58 y/o M with metastatic NSCLC and widespread small foci of metastatic intracranial disease referred for consideration of whole brain radiotherapy
Technique
Dose
Simulation
Contours Per
Plan Evaluation based on NRG CC001
Prescribing memantine for patients with high KPS/ECOG scores planned for HA-WBRT (or even WBRT) is considered standard of care. Memantine slows cognitive decline with no difference in OS or PFS (Brown et al., 2013 and Brown et al., 2020)
Week 1: 5-mg morning dose
Week 2: 5 mg twice a day week 2
Week 3: morning dose 10 mg and evening dose 5 mg
Weeks 4 through 24: 10 mg twice a day
Extended-release Memantine formulation:
Week 1: 7-mg daily dose
Week 2: 14-mg daily
Week 3: 21-mg daily dose
Weeks 4-24: 28-mg daily dose
Looking for additional resources? Watch the hippocampus video featuring Dr. Vinai Gondi, as he discusses hippocampal radiology and contouring on the Anatomy & Radiology Contouring (ARC) Bootcamp.
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